Haplotypes on pig chromosome 3 distinguish metabolically healthy from unhealthy obese individuals
Identifieur interne : 000B10 ( Main/Exploration ); précédent : 000B09; suivant : 000B11Haplotypes on pig chromosome 3 distinguish metabolically healthy from unhealthy obese individuals
Auteurs : Simona D. Frederiksen [Danemark] ; Peter Karlskov-Mortensen [Danemark] ; Sameer D. Pant [Australie] ; Maryse Guerin [France] ; Philippe Lesnik [France] ; Claus B. J Rgensen [Danemark] ; Susanna Cirera [Danemark] ; Camilla S. Bruun [Danemark] ; Thomas Mark [Danemark] ; Merete Fredholm [Danemark]Source :
- PLoS ONE [ 1932-6203 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Obésité, Suidae.
- métabolisme : Obésité.
- Animaux, Cartographie chromosomique, Haplotypes, Polymorphisme de nucléotide simple, Porc miniature, Étude d'association pangénomique.
English descriptors
- KwdEn :
- MESH :
- genetics : Obesity, Swine.
- metabolism : Obesity.
- Animals, Chromosome Mapping, Genome-Wide Association Study, Haplotypes, Polymorphism, Single Nucleotide, Swine, Miniature.
Abstract
We have established a pig resource population specifically designed to elucidate the genetics involved in development of obesity and obesity related co-morbidities by crossing the obesity prone Göttingen Minipig breed with two lean production pig breeds. In this study we have performed genome wide association (GWA) to identify loci with effect on blood lipid levels. The most significantly associated single nucleotide polymorphisms (SNPs) were used for linkage disequilibrium (LD) and haplotype analyses. Three separate haploblocks which influence the ratio between high density lipoprotein cholesterol and total cholesterol (HDL-C/CT), triglycerides (TG) and low density lipoprotein cholesterol (LDL-C) levels respectively were identified on Sus Scrofa chromosome 3 (SSC3). Large additive genetic effects were found for the HDL-C/CT and LDL-C haplotypes. Haplotypes segregating from Göttingen Minipigs were shown to impose a positive effect on blood lipid levels. Thus, the genetic profile of the Göttingen Minipig breed seems to support a phenotype comparable to the metabolic healthy obese (MHO) phenotype in humans.
Url:
DOI: 10.1371/journal.pone.0178828
PubMed: 28570654
PubMed Central: 5453593
Affiliations:
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Frederiksen</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</addr-line></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Karlskov Mortensen, Peter" sort="Karlskov Mortensen, Peter" uniqKey="Karlskov Mortensen P" first="Peter" last="Karlskov-Mortensen">Peter Karlskov-Mortensen</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</addr-line></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Pant, Sameer D" sort="Pant, Sameer D" uniqKey="Pant S" first="Sameer D." last="Pant">Sameer D. Pant</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>School of Animal and Veterinary Sciences, Charles Sturt University, Wagga Wagga, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Animal and Veterinary Sciences, Charles Sturt University, Wagga Wagga</wicri:regionArea><wicri:noRegion>Wagga Wagga</wicri:noRegion></affiliation></author><author><name sortKey="Guerin, Maryse" sort="Guerin, Maryse" uniqKey="Guerin M" first="Maryse" last="Guerin">Maryse Guerin</name><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>INSERM UMR_S1166, Integrative Biology of Atherosclerosis Team, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S1166, Integrative Biology of Atherosclerosis Team, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lesnik, Philippe" sort="Lesnik, Philippe" uniqKey="Lesnik P" first="Philippe" last="Lesnik">Philippe Lesnik</name><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>INSERM UMR_S1166, Integrative Biology of Atherosclerosis Team, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR_S1166, Integrative Biology of Atherosclerosis Team, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="J Rgensen, Claus B" sort="J Rgensen, Claus B" uniqKey="J Rgensen C" first="Claus B." last="J Rgensen">Claus B. J Rgensen</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</addr-line></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Cirera, Susanna" sort="Cirera, Susanna" uniqKey="Cirera S" first="Susanna" last="Cirera">Susanna Cirera</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</addr-line></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Bruun, Camilla S" sort="Bruun, Camilla S" uniqKey="Bruun C" first="Camilla S." last="Bruun">Camilla S. Bruun</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</addr-line></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Mark, Thomas" sort="Mark, Thomas" uniqKey="Mark T" first="Thomas" last="Mark">Thomas Mark</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Novo Nordisk, Scandinavia AB, Region Denmark, Maaloev, Denmark</addr-line></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Novo Nordisk, Scandinavia AB, Region Denmark, Maaloev</wicri:regionArea><wicri:noRegion>Maaloev</wicri:noRegion></affiliation></author><author><name sortKey="Fredholm, Merete" sort="Fredholm, Merete" uniqKey="Fredholm M" first="Merete" last="Fredholm">Merete Fredholm</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</addr-line></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Chromosome Mapping</term><term>Genome-Wide Association Study</term><term>Haplotypes</term><term>Obesity (genetics)</term><term>Obesity (metabolism)</term><term>Polymorphism, Single Nucleotide</term><term>Swine (genetics)</term><term>Swine, Miniature</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cartographie chromosomique</term><term>Haplotypes</term><term>Obésité (génétique)</term><term>Obésité (métabolisme)</term><term>Polymorphisme de nucléotide simple</term><term>Porc miniature</term><term>Suidae (génétique)</term><term>Étude d'association pangénomique</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Obesity</term><term>Swine</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Obésité</term><term>Suidae</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Obesity</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Obésité</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chromosome Mapping</term><term>Genome-Wide Association Study</term><term>Haplotypes</term><term>Polymorphism, Single Nucleotide</term><term>Swine, Miniature</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cartographie chromosomique</term><term>Haplotypes</term><term>Polymorphisme de nucléotide simple</term><term>Porc miniature</term><term>Étude d'association pangénomique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We have established a pig resource population specifically designed to elucidate the genetics involved in development of obesity and obesity related co-morbidities by crossing the obesity prone Göttingen Minipig breed with two lean production pig breeds. In this study we have performed genome wide association (GWA) to identify loci with effect on blood lipid levels. The most significantly associated single nucleotide polymorphisms (SNPs) were used for linkage disequilibrium (LD) and haplotype analyses. Three separate haploblocks which influence the ratio between high density lipoprotein cholesterol and total cholesterol (HDL-C/CT), triglycerides (TG) and low density lipoprotein cholesterol (LDL-C) levels respectively were identified on Sus Scrofa chromosome 3 (SSC3). Large additive genetic effects were found for the HDL-C/CT and LDL-C haplotypes. Haplotypes segregating from Göttingen Minipigs were shown to impose a positive effect on blood lipid levels. Thus, the genetic profile of the Göttingen Minipig breed seems to support a phenotype comparable to the metabolic healthy obese (MHO) phenotype in humans.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Grundy, Sm" uniqKey="Grundy S">SM Grundy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Navarro, E" uniqKey="Navarro E">E Navarro</name></author><author><name sortKey="Funtikova, An" uniqKey="Funtikova A">AN Funtikova</name></author><author><name sortKey="Fito, M" uniqKey="Fito M">M Fito</name></author><author><name sortKey="Schroder, H" uniqKey="Schroder H">H Schroder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bosello, O" uniqKey="Bosello O">O Bosello</name></author><author><name sortKey="Donataccio, Mp" uniqKey="Donataccio M">MP Donataccio</name></author><author><name sortKey="Cuzzolaro, M" uniqKey="Cuzzolaro M">M 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Stamatakis</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>Danemark</li><li>France</li></country><region><li>Hovedstaden</li><li>Île-de-France</li></region><settlement><li>Copenhague</li><li>Paris</li></settlement></list><tree><country name="Danemark"><region name="Hovedstaden"><name sortKey="Frederiksen, Simona D" sort="Frederiksen, Simona D" uniqKey="Frederiksen S" first="Simona D." last="Frederiksen">Simona D. Frederiksen</name></region><name sortKey="Bruun, Camilla S" sort="Bruun, Camilla S" uniqKey="Bruun C" first="Camilla S." last="Bruun">Camilla S. Bruun</name><name sortKey="Cirera, Susanna" sort="Cirera, Susanna" uniqKey="Cirera S" first="Susanna" last="Cirera">Susanna Cirera</name><name sortKey="Fredholm, Merete" sort="Fredholm, Merete" uniqKey="Fredholm M" first="Merete" last="Fredholm">Merete Fredholm</name><name sortKey="J Rgensen, Claus B" sort="J Rgensen, Claus B" uniqKey="J Rgensen C" first="Claus B." last="J Rgensen">Claus B. J Rgensen</name><name sortKey="Karlskov Mortensen, Peter" sort="Karlskov Mortensen, Peter" uniqKey="Karlskov Mortensen P" first="Peter" last="Karlskov-Mortensen">Peter Karlskov-Mortensen</name><name sortKey="Mark, Thomas" sort="Mark, Thomas" uniqKey="Mark T" first="Thomas" last="Mark">Thomas Mark</name></country><country name="Australie"><noRegion><name sortKey="Pant, Sameer D" sort="Pant, Sameer D" uniqKey="Pant S" first="Sameer D." last="Pant">Sameer D. Pant</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Guerin, Maryse" sort="Guerin, Maryse" uniqKey="Guerin M" first="Maryse" last="Guerin">Maryse Guerin</name></region><name sortKey="Lesnik, Philippe" sort="Lesnik, Philippe" uniqKey="Lesnik P" first="Philippe" last="Lesnik">Philippe Lesnik</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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